Department of Pharmacology and Therapeutics                                                                                                             Sefako Makgatho Health Sciences University                                                                                                                               South Africa             

Online Lecture: Pharmacokinetics.

Kinetics of Continuous Drug Administration

With continuous IV infusion, the rate of drug entry into the body is constant.

In the majority of cases, the elimination of a drug is first order; that is, a constant fraction of the agent is cleared per unit of time.

 

Therefore, the rate of drug exit from the body increases proportionately as the plasma concentration increases, and at every point in time, it is proportional to the plasma concentration of the drug. 

Following the initiation of an IV infusion, the plasma concentration of drug rises until the rate of drug eliminated from the body precisely balances the input rate.

Thus, a steady-state is achieved in which the plasma concentration of drug remains constant.

Click below for a Presentation - Kinetics of Continuous Drug Administration.

Thues, a steady-state is achieved in which the plasma concentration of drug remains constant.

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