Department of Pharmacology and Therapeutics                                                                                                             Sefako Makgatho Health Sciences University                                                                                                                               South Africa             

Online Lecture: Endocrine System

Drugs Affecting the Endocrine System - Insulin and Hypoglycemic Drugs

Introduction


Antidiabetic drugs (with the exception of insulin) are all pharmacological agents that have been approved for hypoglycemic treatment in type 2 diabetes mellitus (DM). 

These drugs may be classified according to their mechanism of action as insulinotropic or non-insulinotropic.

They are available as monotherapy or combination therapies, with the latter involving two (or, less commonly, three) antidiabetic drugs and/or insulin.

The exact treatment algorithms are reviewed in the treatment section of diabetes mellitus.

The drug of choice for all type 2 diabetic patients is metformin.

This drug has beneficial effects on glucose metabolism and promotes weight loss or at least weight stabilization.

In addition, numerous studies have demonstrated that metformin can reduce mortality and the risk of complications.

If metformin is contraindicated, not tolerated, or does not sufficiently control blood glucose levels, another class of antidiabetic drug may be administered.

Most antidiabetic drugs are not recommended or should be used with caution in patients with moderate or severe renal failure or other significant comorbidities.

Oral antidiabetic drugs are not recommended during pregnancy or breastfeeding.


Click below for a Presentation - Insulin and Hypoglycemic Drugs.


Literature:

Diabetic foot ulcers heal quickly with nitric oxide technology.

Around the world, 425 million people live with diabetes and upwards of 15 percent develop foot ulcers, which increases their risk of death 2.5 times.

A new nitric oxide-releasing technology has the potential to cut down the healing time of diabetic foot ulcers from 120 days to 21 days.

Read more...