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Pharmacology Teaching and Research
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Pharmacology 3 - Examination Preparation:

                                                                            MBChB 3 and BDS 3

                                                      MCQ, Match Questions and Descriptive Questions:

Name two reasons why formoterol can be used for both acute and long term treatment of asthma.

List four adverse effects of morphine.     

List four adverse effects of phenytoin.  

Name four therapeutic uses of benzodiazepine.

Name two short-acting insulins.   


The following are advantages of sublingual route of drug administration:             

1.    Slow absorption

2.    Convenience of administration

3.    Low incidence of infection

4.    Avoidance of first-pass metabolism

5.    Exposure to first-pass metabolism

 

A = 2,3,4        B = 1,2,3        C = 2,4,5            D = 3,4,5      E = 1,3,4,5 

The following statements are true:                                                                         

1.          Drugs can bind to plasma proteins which would increase the bioavailability of the drug

2.          The intracellular volume is the major water component of the body in which drugs can dissolve

3.          Low molecular weight drugs with both non-polar and polar sections can move through both the endothelial slit junction and cell membrane

4.          Increase in the volume of distribution can cause an increase in the half-life of the drug

5.          A large V D-volume of a drug indicates that most of the drugs are in the extraplasmic space

 

A = 2,3       B = 3,4,5       C = 1,4,5     D = 2,3,4     E = 1,3,4,5 


The following is the correct sequential pharmacokinetic pathway:                  

1.    Metabolism – Administration – Absorption – Elimination – Distribution

2.    Absorption – Administration – Elimination – Metabolism – Distribution

3.    Distribution – Elimination – Absorption – Administration – Metabolism

4.    Administration – Absorption – Distribution – Elimination – Metabolism

5.    Administration – Absorption – Distribution – Metabolism – Elimination 

A = 1  B = 2              C = 3          D = 4            E = 5


The pharmacokinetic parameters of the neuromuscular junction blockers include:       

1.       Parenteral administration

2.       Highly hydrophilic

3.       Highly hydrophobic

4.       Oral administration

5.       Inability to cross the blood brain barrier

 

A = 1,2,4        B = 1,2,5        C = 2,4,5          D = 1,2,3       E = 1,3,4 


Which of the following drugs are long-acting bronchodilators:                             

1.       Salbutamol

2.       Salmeterol

3.       Terbutaline

4.       Fenoterol

5.       Formoterol

 

A = 1,4        B = 2,3        C=3,4          D = 1,5        E = 2,5 


The pharmacokinetic parameters of pilocarpine include:                                       

1.       Stability to hydrolysis by acetylcholinesterase

2.       Excreted by the kidney

3.       Highly hydrophilic

4.       Does not cross the blood brain barrier

5.       Acidification of urine accelerates its clearance

 

A = 1,2,4        B = 1,2,5        C = 2,4,5      D = 1,2,3     E = 1,3,4


β-blockers improve cardiac function in heart failure by:                     

1.       Decreasing heart rate

2.       Increasing heart rate

3.       Increasing renin release

4.       Activating norepinephrine

5.       Decrease mitogenic activity of catecholamines

 A = 1,5         B = 2,5       C = 1,4        D = 4,5         E = 2,3 


The following are side effects of tricyclic antidepressants:                                        

1.       Decreased appetite

2.       Dry mouth

3.       Confusion

4.       Bulimia nervosa

5.       Tachycardia

 

A = 2,3,5    B = 1,2,4      C = 3,4,5      D = 1,4,5      E = 2,3,4 


The following are true about valproic acid:                                                                    

1.       Also used for prophylaxis of migraine                        

2.       Can be used in intractable hiccups

3.       Drug of first choice in the management of tonic-clonic seizures

4.       May be used to control acute manic phase of bipolar disorder

5.       It can be used in the treatment of peripheral neuropathy

 

A = 1,2,5      B = 1,3,4    C = 1,4,5      D = 2,3,4      E = 3,4,5


The potency of inhaled anaesthetic is defined quantitatively as:               

1.       Amount of salivary and bronchial secretions        

2.       Cerebrovascular resistance

3.       Minimum alveolar concentration

4.       Diffusion hypoxia

5.       Long shelf life

 

A = 1           B = 2        C = 3        D = 4       E = 5 


 The following are true regarding salbutamol:                                 

1.    Short-acting B 2-adrenergic agonist

2.    Used in the treatment of asthma

3.    Long-acting B 2-adrenergic agonist

4.    Bronchodilation occurs 30 minutes after inhalation

5.    Effect lasts for 3–4 hours

 

A = 1,2,3     B = 1,2,5      C = 2,4,5     D = 3,4,5       E = All of the above 


Regarding the pharmacokinetics of thyroid hormones:                   

1.    Both T 3 and T 4 are absorbed after oral administration

2.    Calcium preparations increase the absorption of both T 3 and T 4

3.    T 4 can be converted into T 3

4.    Both T 3 and T 4 are metabolized by the P 450 system

5.    Phenobarbital can accelerate the metabolism of both T 3 and T 4

 

A = 1,4,5           B = 1,3,4      C = 2,4,5  D = 1,3,4,5           E = All of the above 


The following are prolactin inhibitors:                            

1.    Somatostatin

2.    Bromocryptine

3.    Quinagolide

4.    Cabergoline

5.    Ocreotide

 

A = 1,3     B = 2,3,4      C = 1,5         D = 1,2        E = 1,4,5

 

Regarding oxytocin:                                                                               

1.    Induces labour

2.    Uterine contractions occur 3 to 5 minutes after IM injection

3.    It is a tocolytic drug

4.    Uterine rupture is a contra-indication

5.    Prostaglandin inhibits oxytocin action

 

A = 1,2,4        B = 2,4,5      C = 1,5      D = 3,4,5      E = All of the above


Which of the following drug inhibits synthesis of beta-(1,3)-glucan?           

1.       Caspofungin

2.       Terbinafine

3.       Grisefulvin

4.       Nystatin

5.       Amphotericin B

 

A = 1          B = 2          C = 3           D = 4           E = 5 


The following are examples of fluoroquinolones:                                                  

 1.      Azithromycin

 2.      Ciprofloxacin

 3.      Amikacin

 4.      Doxycycline

 5.      Levofloxacin

 

 A = 2,3      B = 1,3       C = 1,4       D = 2,5      E = 3,5 


The following drugs are classified as aminoglycosides:                         

1.              Azithromycin

2.              Erythromycin

3.              Gentamycin

4.              Neomycin

5.              Telithromycin

 

A = 1,2         B = 3,4      C = 2,4         D = 1,5        E = 2,5 


Choose the correct association:                                                                              

1.       Methotrexate – antimetabolite

2.       Bleomycin – alkylating agent

3.       Cyclophosphamide – microtubule inhibitor

4.       Vinblastine – antimetabolite

5.       Dactinomycin – antitumor antibiotic

 

A = 1,3,4      B = 1,5       C = 3,4,5      D = 2,4        E = 2,3,4,5 


Choose the correct association:                                                                                 

1.        Whipworm – mebendazole

2.        Roundworm – albendazole

3.        Pork tapeworm - niclosamide

4.        Amoebiasis – metronidazole

5.        Tapeworm – praziquantel

 

A = 1,2,3       B = 2,3,4       C = 3,4,5       D = 1,2,3,4    E = All of the above


Match the following drugs with their classification.                              

 

Drugs:

Beclomethasone

 Ipratropium

Montelukast

Glipizide

Metformin

 Acarbose

 

Classification:

Sulfonylureas                             

Biquanides                                 

Corticosteroid                            

α-Glucosidase inhibitor               

Short acting anticholinergic         

Leukotriene modifier  


Match the following drugs with a corresponding adverse effect.                    

 

Drugs:

Dacarbazine

 Temozolomide

Docetaxel

Spironolactone

Tamoxifen

Danazol

 

Adverse effects:

Myelosuppression            

Hyperkalemia                   

Neurotoxicity                   

 Fluid retention                  

Hot flushes                       

Acne