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Pharmacology Teaching and Research


0354


Pharmacology 3 - Examination Preparation:

                                                                            MBChB 3 and BDS 3

                                                      MCQ, Match Questions and Descriptive Questions:


Pharmacokinetic parameters of drugs include:                                                             (1)

1.    Absorption

2.    Protein binding

3.    Distribution

4.    Metabolism

5.    Elimination

 

A = 1,2,4,5        B = 2,3,4             C = 3,4,5                D = 1,3,4,5           E = All of the above

 

True statements regarding the pK a-value of a drug:                                          (1)

1.    A pH-value at which the concentration of the ionized and unionized forms of the drug are equal

2.    Low value indicates a more acidic drug

3.    High value indicates a more basic drug

4.    Low value indicates a more potent drug

5.    High value indicates a drug with less adverse effects

 

A = 2,3,4            B = 1,2,3                   C = 2,4,5                D = 1,3,4             E = 1,3,5

 

The half-life of a drug can be increased by:                                                                (1)

1.       Decreased renal flow

2.       Increase renal flow

3.       Decreased metabolism

4.       Increased protein binding

5.       Increased metabolism

 

A = 1,2,5        B = 1,3,4             C = 2,3,4                D = 1,2,4               E = 3,4,5 


Correct concept and description combinations:                                          (1)

1.    Passive diffusion : a protein carrier is required to transport a drug

2.    Non-polar : drugs can migrate easily through a cell membrane

3.    Rapid absorption : advantage of the sublingual route of administering a drug

4.    Potency : indication of the amount of drug needed to produce an effect of given magnitude

5.    Pharmacodynamics : what a drug does to the body and how drugs bind to receptors

 

A = 3,4,5          B = 1,4,5   C = 2,3,5               D = 2,3,4,5           E = 1,2,3,4,5



The adverse effects of pyridostigmine include:                                                  (1)

1.      Convulsion

2.      Miosis

3.      Confusion

4.      Urinary urgency

5.      Nausea

A = 1,3,4              B = 2,3,5                 C = 3,4,5                 D=2,4,5                 E = 1,4,

    

Oxymetazoline is a:                                                                                           (1)

1.       Selective α2-adrenergic agonist

2.       Selective β2-adrenergic agonist

3.       Non-selective β-adrenergic agonist

4.       Non-selective α-adrenergic agonist

5.        Selective β1-adrenergic agonist

 

A = 1                       B = 2                         C = 3                         D = 4                        E = 5


Hyperkalemia can be a side effect of which drugs:                                              (1)

1.       Indapamide

2.       Furosemide

3.       Hydrochlorothiazide

4.       Enalapril

5.       Spironolactone

 

A = 1,2                  B = 2,3         C = 3,4         D = 4,5      E = 1,5

 

 

Digoxin:                                                                                                        (1)

1.    Causes vasoconstriction

2.    Is a positive inotrope

3.    Increases AV conduction

4.    Is an alpha-2 antagonist

5.    Decreases AV conduction

 

A = 1,2                 B = 2,3                   C = 3,4                    D = 4,5              E =2, 5 


Choose the correct associations:                                                                                  (1)

1.        Amitriptyline - peripheral neuropathy

2.        Tricyclic antidepressants - dry mouth

3.        Paroxetine – noradrenaline reuptake inhibitor

4.        Tranylcypromine-tyramine cheese like

5.        Buspirone – nicotine addiction

 

A= 1,2,5                  B= 1,2,4                C= 2,4,5                  D=2 ,3,4                  E= 2,3,5

 

Regarding benzodiazepines:                                                                                    (1)

1.        Paradoxically may cause aggression

2.        Diazepam is a drug of choice for absence seizures

3.        Flunitrazepam is known as a “date rape drug”

4.        Midazolam is an ultra-short acting drug

5.        Anterograde amnesia is one of the adverse effects

 

A= 1,2,5                  B= 1,3,4,5             C= 1,2,4                  D= 2,3,4,5               E=1,2,3


Which of the following local anaesthetics are classified as amides:                     (1)

1.      Bupivacaine

2.       Benzocaine

3.       Lignocaine

4.       Procaine

5.       Cocaine

 

A=1,2                    B=2,3                    C=1,3                  D=2,4                   E=4,5

 

The following are adverse effects of propofol:                                                       (1)

1.       Weight gain

2.       Insomnia

3.       Gynaecomastia

4.       Apnoea following induction

5.       Pain at the injection site

 

A=1,2                    B=1,3                    C=2,3                    D=3,4                   E=4,5


Regarding spironolactone:                                                                                 (1)

1.    Is an aldosterone antagonist

2.    Inhibits potassium re-absorption

3.    Inhibits sodium re-absorption

4.    Is an aldosterone agonist

5.    Is a potassium-sparing diuretic

 

A = 1,2,5          B = 1,2,3            C = 1,3,5              D = 2,4,5       E = 2,3,5

 

Hypoglycemic drugs are:                                                                            (1)

1.       Glipizide     

2.       Metformin

3.       Levothyroxine

4.       Acarbose

5.       Clomiphene

 

A = 1,2,4             B = 2,3,4,5              C = 2,3,4               D = 2,3                 E = 1,2,3,4 

 

Which of the following is correct concerning the tetracyclines?          (1)

1.       Predominantly bactericidal

2.       Bind to the 50S subunit ribosome

3.       An example is azithromycin

4.       Broad spectrum

5.       Bacteriostatic

 

A = 1,4                  B = 1,2        C = 2,3                 D = 3,4                          E = 4,5

 

Which of the following are the adverse effects of the sulphonamides?

1.       Crystaluria

2.       Red man syndrome

3.       Inhibition of presynaptic release of acetylcholine

4.       Stevens-Johnson syndrome

5.       Gray baby syndrome

 

A = 2,3                  B = 1,4               C = 1,5                  D = 3,4                 E = 3,5 


Which of the following azoles should be given with a cola beverage for optimal absorption?                                                                                                                   (1)

1.       Fluconazole

2.       Itraconazole

3.       Ketoconazole

4.       Posaconazole

5.       Voriconazole

 

A=1             B=2           C=3             D=4             E=5

 

Which of the following can be used in the treatment of respiratory infections?                                                                                           (1)

1.       Oseltamivir

2.       Tenofovir

3.       Amantadine

4.       Lopinavir

5.       Ribavirin

         

A=1,2,3        #B=1,3,5      C=1,4,5        D=2,3,4        E=All of the above 


The following are antitumor antibiotics:                                                       (1)

1.       Dactinomycin

2.       Fludarabine

3.       Doxorubicin hydrochloride

4.       Bleomycin

5.       Tioquanine

 

A = 3,4                   B = 2,5         C = 1,3,4             D = 1,4,5                E = 2,3,5 


The following will improve the bioavailability of a drug:                               (1)

1.    First pass hepatic metabolism

2.    Non-polarity

3.    Chemical instability

4.    Chemical stability

5.    Resistance to degradative enzymes

 

A = 1,2              B = 2,4,5            C = 3,4,5                 D = 1,3,4,5            E = All of the above

 

The following is the correct sequential pharmacokinetic pathway:                 (1)

1.    Metabolism – Administration – Absorption – Elimination – Distribution

2.    Absorption – Administration – Elimination – Metabolism – Distribution

3.    Distribution – Elimination – Absorption – Administration – Metabolism

4.    Administration – Absorption – Distribution – Elimination – Metabolism

5.    Administration – Absorption – Distribution – Metabolism – Elimination

 

A = 1               B = 2                   C = 3                  D = 4                    E = 5 


The therapeutic use of tamsulosin:                                 (1)

1.       Benign prostatic hyperplasia

2.       Sjogren syndrome

3.       Overactive bladder

4.       Pheochromocytoma

5.       Malignant hyperthermia

 

A = 1         B = 2                      C = 3                     D = 4                  E = 5

 

The pharmacokinetic parameters of pilocarpine include:                               (1)

1.       Stability to hydrolysis by acetylcholinesterase

2.       Excreted by the kidney

3.       Highly hydrophilic

4.       Does not cross the blood brain barrier

5.       Acidification of urine accelerates its clearance

 

A = 1,2,4       B = 1,2,5            C = 2,4,5                D = 1,2,3               E = 1,3,4 


The following are classified as anti-epileptic drugs:                                     (1)

1.       Vigabatrin

2.       Orphenadrine

3.       Topiramate

4.       Oxcarbazepine

5.       Sertraline

 

A = 1,2,5            B = 2,3              C = 1,4,5                D = 4,5                    E = 1,3,4 


The following drugs are classified as TNF-alpha-blocking agents except:

1.        Golimumab

2.        Infliximab,

3.        Adalimumab

4.        Rituximab

5.        Certolizumab

 

A=1                         B=2                         C=3                         D=4                       E=5     


The following are true regarding salbutamol:                                                             (1)

1.    Short-acting B 2-adrenergic agonist

2.    Indicated for asthma treatment

3.    Metabolized in the liver

4.    Bronchodilation occurs 30 minutes after inhalation

5.    Effect lasts for 3 – 4 hours

 

A = 1,2,5              B = 1,2,3,5           C = 2,4,5              D = 3,4,5        E = All of the above

 

Leukotriene modifiers include:                                                                       (1)

1.    Zafirlukast

2.    Montelukast

3.    Tiotropium bromide

4.    Fluticasone

5.    Beclomethasone

 

A =1,4                  B =2,4,5                 C =1,2                 D = 2,3,4,            E = 1,3,4,5


The following drugs inhibit cellular responses to Interleukin-2:          (1)

1.       Tacrolimus

2.       Sirolimus

3.       Mycophenolate mofetil

4.       Azathioprine

5.       Basilixamab

 

A=1,2        B=1,3          C=2,4          D=1,5          E=2,5

 

Which of the following drugs can cause optic neuritis?                                  (1)

1.       Rifampicin

2.       Isoniazid

3.       Ethambutol

4.       Pyrazinamide

5.       Streptomycin

 

A=1                      B=2                      C=3                    D=4                     E=5   


The following drugs are classified as aminoglycosides:                             (1)

1.               Azithromycin

2.               Erythromycin

3.               Gentamycin

4.               Neomycin

5.               Telithromycin

 

A=1,2                   B=3,4                C=2,4                    D=1,5                   E=2,5                                  


Match the following drugs with their indication. Each drug may be used more than once or not at all.                                                                                                      (6)

 

Drugs:

A.      Somatotropin

B.      Clomiphene

C.      Bromocriptine

D.      Danazol

E.       Spironolactone

F.       Glucocorticoids

 

 

Indication:

1. Management of ovulatory infertility                                                                           

2. Treatment of bronchial asthma                                                             

3. Treatment of hyperaldosteronism                                                              

4. Treatment of growth hormone deficiency                                                 

5.  Treatment of endometriosis                                                                     

6.  Treatment of hyperprolactinemia  


Match the following drugs with their classification.                                             (6)

 

Drugs

 

1. Beclomethasone

2. Ipratropium

3.  Montelukast

4. Glipizide

5. Metformin

6. Acarbose

 

Description (Classification)

 

A. Sulfonylureas                                                                              

B. Biquanides                                                                                 

C.  Corticosteroid                                                                            

D.   α-Glucosidase                                                                             

E.  Short acting anticholinergic    


List five adverse effects of morphine.
Name any five adverse effects of phenytoin.
Name the benzodiazepine antagonist.
Name four therapeutic uses of amlodipine
Briefly describe the mechanism of action of the following:     Clopidogrel.